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Limited Long-Term Data: Semaglutide has been studied for a longer period, whereas tirzepatide is newer and still being evaluated for long-term effects

The brand-name premium has shrunk significantly since LillyDirect launched in 2024, but compounded versions still undercut by $100 to $300 per month at therapeutic doses, plus they include the consult fee that brand-name buyers pay separately to their primary care doctor or telehealth provider

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The risk profile differs, too

The list price of Humalog rose from roughly $21 per vial in 1999 to over $274 per vial by 2017 a 13-fold increase over 18 years

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