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Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

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Gamma-oryzanol, a molecule derived from rice bran oil, has been shown to inhibit ferroptosis and cartilage degradation by engaging with the Keap1 and Nrf2 binding sites in IL-1-treated chondrocytes [108]

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It is often referred to as an exercise mimetic because it can produce some of the same metabolic benefits as exercise