a In addition, a number of histologic studies of the effect of sclerotherapy on varicose veins have also concluded that damaged varices are preferentially sclerosed
Recent studies and case reports have highlighted an increased risk of gastroparesis associated with GLP-1 receptor agonist use, particularly semaglutide [8-10]
Obesity Canada will update its medication guidelines to include Wegovy, which is meant to be used in tandem with physical activity and nutrition, he said
However, it should be used cautiously in patients with advanced liver disease and is generally not recommended (23)
Clinical trials show mood-related adverse events occur in a small percentage of users, typically during dose escalation
Seek emergency medical care immediately (call 911 or go to the nearest emergency department) if you experience: Sudden shortness of breath or difficulty breathing Chest pain or pressure Sudden weakness, numbness, or difficulty speaking Coughing up blood Severe leg pain with swelling and warmth Loss of consciousness or severe lightheadedness Contact your healthcare provider within 24 hours for: New or worsening leg swelling, particularly if unilateral Persistent calf pain or tenderness Unexplained fever with leg symptoms Skin changes such as redness or discoloration in the extremities Schedule a routine appointment to discuss: Plans for upcoming surgery or procedures requiring prolonged immobility New medications, particularly hormonal therapies Significant changes in activity level or mobility Concerns about cardiovascular risk factors Persistent or severe gastrointestinal side effects that may affect hydration status Patients should also report common tirzepatide-related adverse effects that may indirectly affect thrombotic risk, such as severe vomiting or diarrhea leading to dehydration, which can increase the risk of blood clots
