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The molecular mechanism underlying lenvatinib-mediated inhibition of protein synthesis remains unclear

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As Dr Sullivan commented, the benefit appears to increase over time rather than fade, and that it behaves like a drug in terms of dose response. Dr Sullivan and colleagues concluded that these results support DMR as a promising, procedure-based strategy to maintain weight loss and potentially enable shorter-duration GLP-1 therapy. In a press release, Dr Sullivan noted, Finding a treatment that allows patients to stop [GLP-1] medications without weight regain or loss of metabolic benefit is a huge unmet need. She continued, These findings indicate that this minimally invasive procedure may provide lasting weight-loss maintenance. Six-month cohort data from the REMAIN-1 trial are expected to be reported late in 2026.